Statistical Mechanics of Viral Entry

Statistical Mechanics and Thermodynamics of Viral Evolution

This paper uses methods drawn from physics to study the life cycle of viruses. The paper analyzes a model of viral infection and evolution using the "grand canonical ensemble" and formalisms from statistical mechanics and thermodynamics. Using this approach we enumerate all possible genetic states of a model virus and host as a function of two independent pressures-immune response and system te...

Molecular docking study of anti-viral FDA-approved drugs as novel entry and replication Ebola viral inhibitors

Background & Objective: Because of the reported high ability of virulence and the lack of appropriate drug of Ebola virus during the last decades, many investigations have been accomplished regarding discovery and the introduction of anti-Ebola drugs. The aim of this research was the bioinformatical study of entry and replication of Ebola viral inhibition by drug repurposing. Materials & Method...

Statistical Mechanics

Statistical Mechanics

where pi ≡ p(x = i). If only M of the K states have non-zero probability and that probability is 1/M then S = logM . In this special case the entropy is the log of the number of occupied states. An analog of this special case in the continuous domain occurs in Liouville’s Theorem. This states that if the volume of phase space (i.e. of the x variable, but now multivariate and continuous) is some...

Statistical mechanics of networks.

We study the family of network models derived by requiring the expected properties of a graph ensemble to match a given set of measurements of a real-world network, while maximizing the entropy of the ensemble. Models of this type play the same role in the study of networks as is played by the Boltzmann distribution in classical statistical mechanics; they offer the best prediction of network p...